One-third of critically ill patients had a mild to moderate dysnatremia at ICU admission. Similarly, mild, moderate and severe hypernatremia (sHR 1.34, 95% CI 1.14 to 1.57 1.51, 95% CI 1.15 to 1.99 and 2.64, 95% CI 2.00 to 3.81 respectively) were independently associated with day-30 mortality. After adjustment for confounder, both moderate and severe hyponatremia (subdistribution hazard ratio (sHR) 1.82, 95% CI 1.002 to 1.395 and 1.27, 95% CI 1.01 to 1.60 respectively) were associated with day-30 mortality. Among these patients, 3,047 (27.4%) had mild to severe hyponatremia at ICU admission, 2,258 (20.3%) had borderline hyponatremia at ICU admission, 1,078 (9.7%) had borderline hypernatremia and 877 (7.9%) had mild to severe hypernatremia. ResultsĪ total of 11,125 patients were included in this study. Borderline hyponatremia and hypernatremia were defined as serum sodium concentration between 135 and 137 mmol/L or 143 and 145 respectively. Mild to severe hyponatremia were defined as serum sodium concentration 145, > 150, and > 155 mmol/L respectively. Unselected patients with ICU stay longer than 48 h were enrolled over a 14-year period were included in this study. Observational study on a prospective database fed by 13 intensive care units (ICUs). To assess the prevalence of dysnatremia, including borderline changes in serum sodium concentration, and to estimate the impact of these dysnatremia on mortality after adjustment for confounders.
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